Abstract:
This work involve the preparation and characterization of new derivatives of pyrimidine compounds from the reaction of chalcones with Thiourea via solid base catalyst (prepared through the reaction of Ba(NO3)2 with AL2O3 at (300-700) °C to obtain metal oxide as a solid base catalyst) and using physical methods. And spectroscopic (melting point, color, product ratio, IR, 1H-NMR, and 13C-NMR), the compositions were confirmed to be correct. The antibacterial activity has been tested in vitro by the disk diffusion assay method against two kinds of bacteria gram positive and gram negative. The minimum inhibitory concentration [MIC] have been determined with the reference of stander drugs, the results showed that the Pyrazoline derivatives are better than growth of both types of bacteria (gram- positive and germ–negative) compared to drug.
Keywords: Chalcones, Solid base catalyst, AL2O3, Pyrimidine, Biological activity.
