Abstract
A sensitive and accurate spectrophotometric method was developed for the determination of chlorpromazine hydrochloride (CPZH) by the oxidative coupling reaction. The method depends on the oxidation of the benzodine reagent using the oxidizing agent potassium periodate in an acidic medium and the addition of a chlorpromazine hydrochloride solution to it. 60 minutes, this is long enough to make many measurements. It gave the highest absorption at the wavelength of 426 nm and followed Beer's law in the range of concentrations 1.25-25 µg/ml. The molar absorptivity was 7177 L. Mol-1.cm-1 and sandal index 0.049 μg. Cm-2 .The method was accurate and compatible, as the recovery 103.024%, the method was successfully applied to chlorpromazine hydrochloride in the pharmaceutical preparation.
