This study aimed to evaluate the role of Vitamin D3 deficiency in women with breast cancer. This study was conducted to estimate tumor necrosis factor (TNF)- α and vitamins (D3, B12, folate), and ferritin levels this study estimate. Some hematological parameters such as hemoglobin (Hb), white blood cells (WBC), platelet level, erythrocyte sedimentation rate (ESR) in women with breast cancer patients. The study started from november 2022 to march 2023, The study population included 50 females, with them 15 in the healthy control (control group) and 35 patients with breast cancer (patient group), whose ages ranged from 25 to 96 years also the mean age is 53 years.
The current study showed a significant low (P< 0.05) in the mean vitamin D3 level (25.97±13.5 ng/ml), vitamin B12 (288.63 ± 78 pg/ml), folate (9.44 ± 4.6 ng/ml), hemoglobin level (11±1.52 g/L), and percentage of packed cell volume (31±10.6) in the patient group with the control group. Also, the current study shows elevated ( P< 0.05 ) in the TNF α and the mean of white blood cells ( 20 ×109 ± 24.5 cell/mm3 ) and Platelet level ( 269 ± 143.8 billion/L ) and ESR ( 203 ± 11.3 mm/hr ) and ferritin level ( 157.4 ± 113.4 ng/ml ) in the patient group among to the control group.
Key words: - Breast cancer, Tumor necrosis factor, Vitamins, Ferritin .
