Abstract
A biochemical study was conducted to identify the effect of Fucus Vesiculosus algae , which is directly related to hypothyroidism in the serum of adult white rabbits dosed with the drug thiourea, by measuring the level of thyroid hormones, antioxidants, and oxidative stress in the blood serum of (28) rabbits. The animals were divided. into four groups, in the following order:
• The positive control group was dosed orally with Distil water.
• The Negative control group: - dosed orally with Thiourea at a concentration of 5 mg/cm3.
• The first group G1 :- was dosed with 5 mg/kg/day of thiourea and then 100 mg/kg/day of crude extract of Fucus Vesiculosus algae .
• As for group G2, they were dosed with 5 mg/kg/day of thiourea and then 150 mg/kg/day of the crude extract of Fucus Vesiculosus algae . The results showed the following:
The results showed that the level of TSH showed a significant decrease in all groups compared to the positive control group in the fourth week of dosing. Also the T3 hormone level showed a significant increase in all groups C1, G1, and G2 compared to the positive control in the fourth week of dosing. In addition, the T4 hormone showed a significant increase in all groups C2, G1, and G2 in the fourth week of dosing. As well as the glutathione level, it showed a significant decrease in all groups compared to the positive control group in the fourth week of dosing. Also the malondialdehyde showed a significant increase in the serum of the groups compared to the positive control group in the fourth week of dosing.
Keywords: Fucus Vesiculosus algae , Thyroid hormones, thiourea, glutathione, malondialdehyde.
