Antibacterial Effects of ZnO Nanoparticles in Combination with Other antibiotics

Authors

  • Ruaa Maan Department of Forensic Chemistry, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq
  • Alyaa Hussein Ashour . College of medicine, Al-Nahrain University, Baghdad, Iraq
  • Raneen Salam Al-Obaidi Alnahrain renewable energy research Center, Al-Nahrain University, Baghdad, Iraq
  • Dina Hameed Haider Department of Forensic Chemistry, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq
  • Dunya Abdullah Mohammed Department of Forensic Biology, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq
  • Wassan Hassan Department of Forensic Engineering, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq

Keywords:

Antibacterial activity, ZnO Nanoparticles, antibiotic resistance, Gram-positive bacteria, Gram- negative bacteria

Abstract

     This study investigates the antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) against Acinetobacter baumannii plus Staphylococcus aureus. The well diffusion method was used to estimate the inhibition zones of different concentrations of ZnO-NPs, as well as combined with ciprofloxacin and ceftriaxone. The results indicate that high concentrations of ZnO-NPs alone exhibit strong antibacterial activity and statistically, the p-value is non-significant, and their combination with antibiotics enhances bacterial inhibition. The mixture of ZnO-NPs with ciprofloxacin and ceftriaxone significantly enhanced the antibacterial effect against both Gram-positive and negative bacteria, suggesting a potential strategy for overcoming antibiotic resistance.

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Published

2026-01-22

Issue

Vol. 1 No. 10 (2025): JOURNAL OF NATURAL AND APPLIED SCIENCES URAL NO10 V1

Section

Articles

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